BDBM279135 5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazol-3-yl]methyl]-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::BDBM425076::US10034861, Example 166::US10512632, Example 166::US10766893, Example S166::US10806718, Example 166::US11026923, Example 166::US11491140, Example 166::US11634416, Example 166

SMILES CCOc1ncccc1-c1cc(NCc2cc(CF)on2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=XUHFADCPGYKQAR-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 279135   

LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  33nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  7.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279135(5-(2-ethoxy-3-pyridyl)-N-[[5-(fluoromethyl)isoxazo...)
Affinity DataIC50:  0.160nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent