BDBM280408 US10030012, Example 38::ethyl 4-[4-(3- methoxypyridin- 2-yl)piperidin-1- yl]azepane-1- carboxylate

SMILES CCOC(=O)N1CCCC(CC1)N1CCC(CC1)c1ncccc1OC

InChI Key InChIKey=GWGLXRCCVIVRSY-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 280408   

TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  30nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  2.52E+3nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM280408(US10030012, Example 38 | ethyl 4-[4-(3- methoxypyr...)
Affinity DataEC50:  160nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent