BDBM281728 (+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluo-3-methylbutanoyl]amino}phenyl)-4-methylpentanoic acid (diastereomer 1)::US10023528, Example 1::US10259776, Example 2
SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1
InChI Key InChIKey=IYIIYLRYFLBIJB-KVCBOLPTSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 281728
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataEC50: 22nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataEC50: 89nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataEC50: 22nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair