BDBM283996 E22::US10023564, Example 22

SMILES CCc1nc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)no1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 283996   

TargetRhodopsin kinase GRK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  3.50E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  180nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  160nMAssay Description:Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  380nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  410nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent