BDBM284771 US10023575, Example 62::US10023575, Example 91a::US10023575, Example 91b::US10479794, Example 91b::US10875867, Example 62::US11691977, Example 62

SMILES Cc1nn2cc(cnc2c1C(=O)NC1(CCOCC1(C)O)c1ncc(cc1F)C(F)(F)F)C1CC1

InChI Key InChIKey=SUPHUTXLXXHJQM-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284771   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284771(US10023575, Example 62 | US10023575, Example 91a |...)
Affinity DataIC50:  7.16E+3nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284771(US10023575, Example 62 | US10023575, Example 91a |...)
Affinity DataIC50:  127nMAssay Description:Assay Principle: The PDE reaction cleaves cAMP to AMP. The IMAP system (Molecular Device) using fluorescence polarization (FP) as detection principle...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent