BDBM285681 US10077273, Compound HK-11

SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(Cl)cc(c1)C(F)(F)F

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285681   

TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285681(US10077273, Compound HK-11)
Affinity DataIC50:  100nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent