BDBM28574 1-sulfonylindazole, 6c::3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]propanamide

SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12

InChI Key InChIKey=YSQAQADMLFUOTE-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 28574   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi:  0.5nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi:  155nM ΔG°:  -9.19kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi: >2.00E+3nM ΔG°: >-7.69kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi: >2.00E+3nM ΔG°: >-7.69kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi: >2.00E+3nM ΔG°: >-7.69kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi: >2.00E+3nM ΔG°: >-7.69kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi:  5.10E+3nM ΔG°:  -7.14kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi:  6.40E+3nM ΔG°:  -7.01kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed