BDBM286062 (R)-N-(2-(4-Chlorophenyl)-1-(tetrahydrofuran-3-yl)-1H-indol-5-yl)-2-(difluoromethyl)-5-(((2-fluoro-2-methyl-propanoyl)amino)methyl)nicotinamide::US10081629, Example 47

SMILES CC(C)(F)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc1ccc2n([C@@H]3CCOC3)c(cc2c1)-c1ccc(Cl)cc1

InChI Key InChIKey=ORSREGWXHINSGZ-JOCHJYFZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286062   

TargetProstaglandin E synthase(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286062((R)-N-(2-(4-Chlorophenyl)-1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50:  18.9nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM286062((R)-N-(2-(4-Chlorophenyl)-1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50:  5.72nMAssay Description:mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent