BDBM286241 US11220518, Ex. No. A6::US11780853, Example A6::US9518060, Example A6

SMILES CNc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)N(C)C[C@@H]2C)C3(C)C)n1

InChI Key InChIKey=LRZKRKDRHKBUGU-LBPRGKRZSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286241   

TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286241(US11220518, Ex. No. A6 | US11780853, Example A6 | ...)
Affinity DataKi:  8.75nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type Isoform 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286241(US11220518, Ex. No. A6 | US11780853, Example A6 | ...)
Affinity DataKi:  10.8nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286241(US11220518, Ex. No. A6 | US11780853, Example A6 | ...)
Affinity DataKi:  10.8nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286241(US11220518, Ex. No. A6 | US11780853, Example A6 | ...)
Affinity DataKi:  10.8nMpH: 7.4Assay Description:Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent