BDBM286257 N2-ethyl-5-fluoro-N4-(5-{[(2S,5R)-4-(3-methoxypropyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyrimidine-2,4-diamine acetate salt::US11220518, Ex. No. B1::US11780853, Example B1::US9518060, Example B1

SMILES CCNc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CCCOC)C[C@@H]2C)C3(C)C)n1

InChI Key InChIKey=XEGXJBWNOCJXQI-CVEARBPZSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286257   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286257(N2-ethyl-5-fluoro-N4-(5-{[(2S,5R)-4-(3-methoxyprop...)
Affinity DataKi:  5.09nMpH: 7.4Assay Description:Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type Isoform 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286257(N2-ethyl-5-fluoro-N4-(5-{[(2S,5R)-4-(3-methoxyprop...)
Affinity DataKi:  5.09nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286257(N2-ethyl-5-fluoro-N4-(5-{[(2S,5R)-4-(3-methoxyprop...)
Affinity DataKi:  5.09nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent