BDBM288436 (E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2-methylpropyl)-7-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)phenyl)acrylic acid::US10087191, Example 1

SMILES CC1Cc2cc3OCOc3cc2C(N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F

InChI Key InChIKey=DTLYVZWLSCXRPR-SNAWJCMRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288436   

TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM288436((E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2...)
Affinity DataIC50:  0.770nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent