BDBM290889 1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]- 5-methoxy-3-(1- phenyl-1H-pyrazol- 5-yl)pyridazin- 4(1H)-one::US9579407, Example 00162
SMILES COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)C1CCOCC1
InChI Key InChIKey=PFQQSVKFDVADLG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 290889
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 0.770nMAssay Description:Inhibition of PDE10A (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 0.770nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
Affinity DataKd: 4.70nMAssay Description:Binding affinity to PDE10A in rat brain nucleus accumbens by saturation binding assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding affinity to PDE10A in rat brain caudate-putamen by saturation binding assayMore data for this Ligand-Target Pair