BDBM29142 substituted chalcone, 5i

SMILES COc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1

InChI Key InChIKey=PSHLSUYKYJMBFH-RUDMXATFSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 29142   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Sapienza University of Rome

LigandPNGBDBM29142(substituted chalcone, 5i)
Affinity DataIC50:  4.40nMpH: 7.4 T: 2°CAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Sapienza University of Rome

LigandPNGBDBM29142(substituted chalcone, 5i)
Affinity DataAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Sapienza University of Rome

LigandPNGBDBM29142(substituted chalcone, 5i)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM29142(substituted chalcone, 5i)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by FluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM29142(substituted chalcone, 5i)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed