BDBM297514 US10118902, Example 16::US10584103, Example 16::{2-(1-fluoro-cyclopropyl)-4-[4-(2- methoxy-phenyl)-piperidin-1-yl]- quinazolin-6-yl}-(2-methoxy- ethyl)-methyl-amine

SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1(F)CC1

InChI Key InChIKey=PUOWKWPAXWOGIH-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297514   

TargetNeurotensin receptor type 1(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297514(US10118902, Example 16 | US10584103, Example 16 | ...)
Affinity DataEC50:  1.25E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297514(US10118902, Example 16 | US10584103, Example 16 | ...)
Affinity DataEC50:  1.06E+3nMAssay Description:Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated be...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297514(US10118902, Example 16 | US10584103, Example 16 | ...)
Affinity DataEC50:  1.25E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent