BDBM298343 7-((4-carboxyphenyl)carbamoyl)-3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-7-(cyclopropylmethyl)-6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide (Example 21 and 22)::US10123995, Example 21::US10123995, Example 22

SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)C2(CC3CC3)CCc3cc(c[n+]([O-])c23)-c2cc(Cl)ccc2-n2cnnn2)cc1

InChI Key InChIKey=GEXURDHGLNAAJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 298343   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM298343(7-((4-carboxyphenyl)carbamoyl)-3-(5-chloro-2-(1H-t...)
Affinity DataIC50:  178nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM298343(7-((4-carboxyphenyl)carbamoyl)-3-(5-chloro-2-(1H-t...)
Affinity DataIC50: >870nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent