BDBM299190 N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindolin-2-yl)pyrimidin-4-amine::US10125144, Example 18::US11311541, Example 198

SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1

InChI Key InChIKey=QWVKCTINPBKQMS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 299190   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50:  2nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50:  7.07E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299190(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Affinity DataIC50:  2nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent