BDBM301444 4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]methyl}-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile::US10131670, Example 35

SMILES Nc1ncnn2c(Cc3cc(no3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)(F)F)c12

InChI Key InChIKey=ABBVLSDKXIAUGK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301444   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301444(4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...)
Affinity DataEC50:  4.65nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301444(4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...)
Affinity DataEC50:  4nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent