BDBM304509 (R)-2-(2-(4-(4-(hydroxymethyl)-3-(methylsulfonyl)phenyl)-2-isopropylpiperazin-1-yl)-4-(trifluoromethyl)pyrimidin-5-yl)-2-methylpropanenitrile::US10144715, Compound 25-1

SMILES CC(C)[C@@H]1CN(CCN1c1ncc(c(n1)C(F)(F)F)C(C)(C)C#N)c1ccc(CCO)c(c1)S(C)(=O)=O

InChI Key InChIKey=NEGSIYPKPKVQAA-FQEVSTJZSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304509   

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304509((R)-2-(2-(4-(4-(hydroxymethyl)-3-(methylsulfonyl)p...)
Affinity DataKi:  4nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304509((R)-2-(2-(4-(4-(hydroxymethyl)-3-(methylsulfonyl)p...)
Affinity DataKi:  32nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent