BDBM306574 (1S,8R)-N-[(4- carbamimidoylphenyl)methyl]- 12-(5-chlorothiophen-2-yl)-15- oxatetracyclo- [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 217

SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(Cl)s2)cc1

InChI Key InChIKey=MHQDMBCAMZUIKY-LOSJGSFVSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306574   

TargetPlasma kallikrein(Homo sapiens (Human))
Global Blood Therapeutics

US Patent
LigandPNGBDBM306574((1S,8R)-N-[(4- carbamimidoylphenyl)methyl]- 12-(5-...)
Affinity DataIC50:  2nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent