BDBM312685 US9604998, Example 84

SMILES COc1cc(F)c(CCN2CCN3C[C@H](OC[C@@H]3C2)c2ccc3C(=O)OCc3c2C)cc1C#N

InChI Key InChIKey=OUAXOZYEMCLIHH-DFBJGRDBSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312685   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312685(US9604998, Example 84)
Affinity DataIC50:  50nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent