BDBM31537 pyrazolo[4,3-h]quinazoline-3-carboxamide, 20

SMILES Cn1nc(C(=O)Nc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12

InChI Key InChIKey=VRZQAXBLQMWLAF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 31537   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50:  574nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50:  574nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50:  574nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31537(pyrazolo[4,3-h]quinazoline-3-carboxamide, 20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed