BDBM315700 US10172859, Example 124::US11065253, Example 124::US9732094, Example 124::[2,4-Difluoro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(2-fluoro- 4-methoxy- phenyl)methanol1H NMR (400 MHz, DMSO-d6) ppm = 9.09 (s,1H), 7.70 (t, J = 8.8, 1H), 7.62-7.44 (m, 3H),7.25 (t, J = 9.2, 1H), 7.20 (d, J = 2.4, 1H), 6.82(dd, J = 8.6, 2.5, 1H), 6.74 (dd, J = 12.6, 2.5,1H), 6.34 (d, J = 4.6, 1H), 6.28 (d, J = 4.6, 1H),3.82-3.71 (m, 7H), 3.49-3.41 (m, 4H)

SMILES COc1ccc(C(O)c2cc(c(F)cc2F)-c2ncnc3cc(ccc23)N2CCOCC2)c(F)c1

InChI Key InChIKey=DRCQLIDBEVYMKC-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315700   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315700(US10172859, Example 124 | US11065253, Example 124 ...)
Affinity DataKi: <1.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315700(US10172859, Example 124 | US11065253, Example 124 ...)
Affinity DataKi: <1.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315700(US10172859, Example 124 | US11065253, Example 124 ...)
Affinity DataIC50:  18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315700(US10172859, Example 124 | US11065253, Example 124 ...)
Affinity DataIC50:  18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315700(US10172859, Example 124 | US11065253, Example 124 ...)
Affinity DataIC50:  19nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent