BDBM315937 US10172859, Example 361::US11065253, Example 361::US9732094, Example 361::[2-Chloro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]pyrrolo[1,2-a]- pyrazin-1-ylmethanol1H NMR (500 MHz, DMSO-d6) ppm = 9.08 (s,1H), 8.22-8.19 (m, 1H), 8.14 (d, J = 2.2, 1H), 7.89(d, J = 9.4, 1H), 7.76 (dd, J = 2.5, 1.3, 1H), 7.70 (dd,J = 8.2, 2.2, 1H), 7.61 (d, J = 8.2, 1H), 7.53 (dd,J = 9.5, 2.6, 1H). 7.43 (d, J = 4.8, 1H), 7.21 (d,J = 2.6, 1H), 7.00-6.97 (m, 1H), 6.93-6.90 (m,1H), 6.45-6.40 (m, 2H), 3.81-3.76 (m, 4H),3.48-3.42 (m, 4H).

SMILES OC(c1cc(ccc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1)c1nccn2cccc12

InChI Key InChIKey=MAVRQQXHKQFAMV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315937   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315937(US10172859, Example 361 | US11065253, Example 361 ...)
Affinity DataKi: <1.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315937(US10172859, Example 361 | US11065253, Example 361 ...)
Affinity DataKi: <1.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315937(US10172859, Example 361 | US11065253, Example 361 ...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315937(US10172859, Example 361 | US11065253, Example 361 ...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315937(US10172859, Example 361 | US11065253, Example 361 ...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent