BDBM316006 US10172859, Example 429::US11065253, Example 429::US9732094, Example 429::[2-Chloro-4-fluoro-5- (7-morpholin-4-yl- quinazolin-4-yl)- phenyl]thieno[2,3-d}- pyrimidin-4-yl- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.07 (s,1H), 9.05 (s, 1H), 8.46 (d, J = 5.6, 1H), 7.75 (d,J = 7.6, 1H), 7.72 (d, J = 9.6, 1H), 7.61 (d, J = 5.6,1H), 7.55-7.49 (m, 2H), 7.20 (d, J = 5.0, 1H), 7.19-7.17 (m, 1H), 6.42 (d, J = 5.1, 1H), 3.80-3.75 (m,4H), 3.46-3.42 (m, 4H).

SMILES OC(c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1)c1ncnc2sccc12

InChI Key InChIKey=WSXQRVAJDUCHLW-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 316006   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM316006(US10172859, Example 429 | US11065253, Example 429 ...)
Affinity DataKi: <1.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM316006(US10172859, Example 429 | US11065253, Example 429 ...)
Affinity DataKi: <1.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM316006(US10172859, Example 429 | US11065253, Example 429 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM316006(US10172859, Example 429 | US11065253, Example 429 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM316006(US10172859, Example 429 | US11065253, Example 429 ...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent