BDBM31657 imidazole-dioxolane, 9

SMILES Oc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1

InChI Key InChIKey=YSVCQFYCUWODIY-RBBKRZOGSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 31657   

TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50:  1.59E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:CYP2E1 hydroxylation of p-nitrophenol was determined by the spectrophotometric measurement of 4-nitrocatechol. Briefly, reaction mixture consisting o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO-2 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50:  1.40E+3nMAssay Description:CYP3A1/3A2-catalyzed erythromycin N-demethylase activity was determined by the spectrophotometric measurement of formaldehyde. Briefly, reaction mixt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM31657(imidazole-dioxolane, 9)
Affinity DataIC50:  7.00E+3nMpH: 7.4Assay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed