BDBM317531 6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl]amino}ethyl]-1,2-dihydroquinolin-2-one::US9624175, Compound I-46

SMILES CC(C)CN1C(=O)OCc2cnc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)nc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317531   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM317531(6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Therapeutics

US Patent
LigandPNGBDBM317531(6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2...)
Affinity DataIC50: <100nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent