BDBM318028 2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-methyl-3,5,6,7- tetrahydropyrido[2,3-d]pyrimidin- 4-one dihydrochloride::US9624218, Example 29

SMILES COc1ccccc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1

InChI Key InChIKey=CLMCMCIANXSSCI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318028   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318028(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Affinity DataIC50:  18.4nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318028(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Affinity DataIC50:  6.07E+3nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318028(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Affinity DataIC50:  14.1nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent