BDBM318476 Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl-1,2,4,5-tetrahydroimidazo[1,5,4-de][1,4]benzoxazine-5-carboxylate::US10464947, Example 23::US11498926, Example 23::US9624241, Example 23

SMILES CCOC(=O)C1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318476   

TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [353-454](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [58-164](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM318476(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent