BDBM31895 Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20.2HCl

SMILES Clc1ccc(cc1)-c1nc2ccc(cc2c2OCCCc12)C(=O)NCCCCCCCCNc1c2CCCCc2nc2cc(Cl)ccc12

InChI Key InChIKey=RJZPCUVMLZBWGD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 31895   

TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  7.03nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using AChE from bovine or human erythrocytes and acetylthiocho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universitat De Barcelona

LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  10.4nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using AChE from bovine or human erythrocytes and acetylthiocho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  7nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  223nMAssay Description:Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM31895(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 20....)
Affinity DataIC50:  331nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using BChE from human serum and butyrylthiocholine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed