BDBM319552 4-(4-Methyl-1H-imidazol-2-yl)-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-(propan-2-yloxy)isoquinoline-6-carboxamide::US10174000, Example 3

SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(-c3nc(C)c[nH]3)c2cc1C(N)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319552   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM319552(4-(4-Methyl-1H-imidazol-2-yl)-1-{[(2S)-5-oxopyrrol...)
Affinity DataIC50:  230nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM319552(4-(4-Methyl-1H-imidazol-2-yl)-1-{[(2S)-5-oxopyrrol...)
Affinity DataIC50:  2.90E+3nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent