BDBM319560 1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-7-(propan-2-yloxy)-4-[(pyridin-3-ylsulfonyl)amino]isoquinoline-6-carboxamide::US10174000, Example 11

SMILES CC[C@@H]1CC(=O)N[C@@H]1COc1ncc(NS(=O)(=O)c2cccnc2)c2cc(C(N)=O)c(OC(C)C)cc12

InChI Key InChIKey=GAIDFZHUMZPMKV-QVKFZJNVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319560   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM319560(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Affinity DataIC50:  1.30E+3nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM319560(1-{[(2S,3R)-3-Ethyl-5-oxopyrrolidin-2-yl]methoxy}-...)
Affinity DataIC50: >1.00E+5nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent