BDBM320144 N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314

SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1

InChI Key InChIKey=PEAPNGOBIXQGEJ-QGZVFWFLSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 320144   

TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  35nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  35nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  192nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  35nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  35nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320144(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent