BDBM320728 (R)- or (S)-1-(Cyclopropyl(2- fluoro-4- (trifluoromethyl)phenyl)methyl)- 6-(dimethylamino)-3- (hydroxymethyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one::US10174037, Example 134::US10174037, Example 135
SMILES CN(C)c1nc2n(nc(CO)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1F)C(F)(F)F
InChI Key
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 320728
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.0470nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.600nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Affinity DataKi: 0.720nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair