BDBM3289 4-(Benzylamino)quinazoline deriv. 40::CHEMBL545541::N-benzyl-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC

InChI Key InChIKey=FVWVAEZYXLGVIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3289   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3289(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Affinity DataIC50:  10nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM3289(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3289(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article