BDBM329015 4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)- 3-methoxy-N- (methylsulfonyl)benzamide::4-(5-chloro-6-(3,5-dichlorophenoxy)-3-pyridinyl)-3-methoxy-N-(methylsulfonyl)benzamide::US9663508, Example 348

SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(Cl)c1)C(=O)NS(C)(=O)=O

InChI Key InChIKey=MNRWYZJQBAAMKH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329015   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329015(4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)-...)
Affinity DataIC50:  34.5nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM329015(4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)-...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329015(4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)-...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM329015(4-(5-chloro-6-(3,5- dichlorophenoxy)-3-pyridinyl)-...)
Affinity DataIC50:  5.74E+3nMAssay Description:293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent