BDBM329146 4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chloro-3-pyridinyl)-2-fluoro-5-methyl-N-(methylsulfonyl)benzamide::Mixture of 4-(6-((1R)-1-(1,3- benzothiazol-2-yl)ethoxy)-5- chloro-3-pyridinyl)-2-fluoro-5- methyl-N- (methylsulfonyl)benzamide and 4-(6-((1S)-1-(1,3-benzothiazol- 2-yl)ethoxy)-5-chloro-3- pyridinyl)-2-fluoro-5-methyl- N-(methylsulfonyl)benzamide::US9663508, Example 647::US9663508, Example 709

SMILES C[C@@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1nc2ccccc2s1

InChI Key InChIKey=QHNDRICPFGSWQW-CYBMUJFWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329146   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329146(4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chlo...)
Affinity DataIC50:  76nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329146(4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chlo...)
Affinity DataIC50: >3.00E+3nMAssay Description:293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329146(4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chlo...)
Affinity DataIC50:  34.9nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329146(4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chlo...)
Affinity DataIC50: >3.00E+3nMAssay Description:293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent