BDBM3294 4-Anilinoquinazoline deriv. 45::4-N-(3-bromophenyl)quinazoline-4,6-diamine::Anilinoquinazoline, 4b::CHEMBL52765
SMILES Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
InChI Key InChIKey=IZQHULBHKPGOAP-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 3294
Affinity DataIC50: 0.780nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Mus musculus)
Mcgill University Health Center/Royal Victoria Hospital
Curated by ChEMBL
Mcgill University Health Center/Royal Victoria Hospital
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital
Curated by ChEMBL
Mcgill University Health Center/Royal Victoria Hospital
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of EGFR-TK in human A431 cell lysate assessed as reduction in EGF stimulated kinase activity after 60 mins using biotinylated peptide subs...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by western blotMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by western blotMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant EGFR expressed in baculovirus infected Sf9 cells after 1 hr by DELFIA/time-resolved fluorometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of EGFR after 50 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair