BDBM330401 (S)—N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine::US9725439, 3

SMILES Fc1ccc(Nc2ncnc3cc(O[C@H]4CCOC4)c(NC4CN(C4)C(=O)C=C)cc23)cc1Cl

InChI Key InChIKey=RSWAKAGASMNZDR-INIZCTEOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330401   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330401((S)—N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro...)
Affinity DataIC50:  0.600nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330401((S)—N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro...)
Affinity DataIC50:  0.200nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent