BDBM333177 US10196436, Compound 27::US10196436, Compound 51

SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(F)cccc3NC(=O)C=C)ncc2c1

InChI Key InChIKey=GFVDVDKVQWXEON-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 333177   

TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM333177(US10196436, Compound 27 | US10196436, Compound 51)
Affinity DataIC50: <10nMAssay Description:In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM333177(US10196436, Compound 27 | US10196436, Compound 51)
Affinity DataIC50: >1.00E+3nMAssay Description:In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM333177(US10196436, Compound 27 | US10196436, Compound 51)
Affinity DataIC50:  55nMAssay Description:In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM333177(US10196436, Compound 27 | US10196436, Compound 51)
Affinity DataIC50:  55nMAssay Description:In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent