BDBM333707 1-(3-(2- fluoropropan-2- yl)isoxazol-5- yl)-3-(3-(7- hydroxy-6- methoxy- quinazolin- 4-yloxy) phenyl)urea::US9730937, Example 257

SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(no4)C(C)(C)F)c3)ncnc2cc1O

InChI Key InChIKey=QTEHHMZLVUOFOS-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333707   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333707(1-(3-(2- fluoropropan-2- yl)isoxazol-5- yl)-3-(3-(...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333707(1-(3-(2- fluoropropan-2- yl)isoxazol-5- yl)-3-(3-(...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM333707(1-(3-(2- fluoropropan-2- yl)isoxazol-5- yl)-3-(3-(...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent