BDBM335463 (3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- methoxypteridin-4- yl)amino)phenyl)-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 22
SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ncnc2n1
InChI Key InChIKey=YIFGFQXGTFGZHO-VXKWHMMOSA-N
Data 3 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 335463
Affinity DataKi: 11nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...More data for this Ligand-Target Pair
Affinity DataKi: >9.40E+3nMAssay Description:The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...More data for this Ligand-Target Pair