BDBM338396 8-(3-fluoro-4-(((3S,6R)-3-methyl- 1,1-dioxido-6-phenyl-1,2-thiazinan- 2-yl)methyl)phenyl)-3-methyl-1- oxa-8-azaspiro[4.5]decan-2-one::US9751873, Example 84

SMILES CC1CC2(CCN(CC2)c2ccc(CN3[C@@H](C)CC[C@H](c4ccccc4)S3(=O)=O)c(F)c2)OC1=O

InChI Key InChIKey=TVNJUGUIGUCMFZ-XGMIRAJKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 338396   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM338396(8-(3-fluoro-4-(((3S,6R)-3-methyl- 1,1-dioxido-6-ph...)
Affinity DataIC50:  276nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent