BDBM341396 2-((2-chloro-6-(dimethylamino)pyridin-3-yl)oxy)-1-(5-(4-cyclopropyl-2-fluorophenyl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone::US9765092, Example 1.6.22

SMILES CN(C)c1ccc(OCC(=O)N2CCc3nc4sc(C)nn4c3C2c2ccc(cc2F)C2CC2)c(Cl)n1

InChI Key InChIKey=JUNAJUXUXYEGQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341396   

TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341396(2-((2-chloro-6-(dimethylamino)pyridin-3-yl)oxy)-1-...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent