BDBM345138 1-(4-((2-((2-Oxoindolin-6-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea::US9783556, Example 10

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc4CC(=O)Nc4c3)n2)c2ccccc12)[Si](C)(C)C

InChI Key InChIKey=RAKMRLALDGQSIF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345138   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
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US Patent
LigandPNGBDBM345138(1-(4-((2-((2-Oxoindolin-6-yl)amino)pyrimidin-4-yl)...)
Affinity DataIC50:  541nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM345138(1-(4-((2-((2-Oxoindolin-6-yl)amino)pyrimidin-4-yl)...)
Affinity DataIC50:  1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM345138(1-(4-((2-((2-Oxoindolin-6-yl)amino)pyrimidin-4-yl)...)
Affinity DataIC50:  990nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM345138(1-(4-((2-((2-Oxoindolin-6-yl)amino)pyrimidin-4-yl)...)
Affinity DataIC50:  19nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent