BDBM346171 (4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′-trifluoromethyl-[4,5′]bipyrimidinyl-6-yl)-4-methyl-5-thiazol-2-yl-oxazolidin-2-one::US10202371, Example 1

SMILES C[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1

InChI Key InChIKey=ONCWHTARVIIEDJ-IINYFYTJSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 346171   

LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  6nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  9nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  11.3nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  251nMAssay Description:TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  31nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  20nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346171((4S,5R)-3-(2′-Amino-2-morpholin-4-yl-4′...)
Affinity DataIC50:  92nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent