BDBM347316 2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,3-difluorophenyl)-N-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)acetamide::US9789100, Example 4

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(OCCO)c(c2)C(F)(F)F)c(F)c1F

InChI Key InChIKey=DBAIOFPQXZMYCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347316   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347316(2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,3-...)
Affinity DataIC50: <100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347316(2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,3-...)
Affinity DataIC50:  300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347316(2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,3-...)
Affinity DataIC50:  300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent