BDBM347324 N-(6-(2-Cyanopropan-2-yl)-5-(trifluoromethyl)pyridin-3-yl)-2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)acetamide hydrochloride::US9789100, Example 12

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(c(c2)C(F)(F)F)C(C)(C)C#N)c(F)c1

InChI Key InChIKey=GIDPPWGMEPLHMN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347324   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347324(N-(6-(2-Cyanopropan-2-yl)-5-(trifluoromethyl)pyrid...)
Affinity DataIC50: <100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347324(N-(6-(2-Cyanopropan-2-yl)-5-(trifluoromethyl)pyrid...)
Affinity DataIC50:  300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347324(N-(6-(2-Cyanopropan-2-yl)-5-(trifluoromethyl)pyrid...)
Affinity DataIC50:  300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent