BDBM347342 2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide::US9789100, Example 30

SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1

InChI Key InChIKey=IDXKJSSOUXWLDB-UHFFFAOYSA-N

Data  6 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 347342   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: <100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: <100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: <100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataKd:  20nMAssay Description:Binding affinity to RET in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of RET phosphorylation in human TT cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataKd:  40nMAssay Description:Binding affinity to DDR1 in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataKd:  20nMAssay Description:Binding affinity to RET in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human RET using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50:  109nMAssay Description:Inhibition of human KDR using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM347342(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataKd:  40nMAssay Description:Binding affinity to DDR1 in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed