BDBM350139 1-[8-amino-1-(4-{(1R)-1- hydroxy-1-[3- (trifluoromethyl)phenyl] ethyl}phenyl)imidazo[1,5- a]pyrazin-3- yl]cyclopropanecarboxylic acid::US10208047, Example 7

SMILES C[C@@](O)(c1ccc(cc1)-c1nc(n2ccnc(N)c12)C1(CC1)C(O)=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=MUVZSHWSEKBKMG-HSZRJFAPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350139   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350139(1-[8-amino-1-(4-{(1R)-1- hydroxy-1-[3- (trifluorom...)
Affinity DataIC50:  614nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent