BDBM350167 (1R,3r,5S,6s)-3-[8-amino-1- (4-{(1R)-1-hydroxy-1-[3- (trifluoromethyl)phenyl] ethyl}phenyl)imidazo[1,5- a]pyrazin-3- yl]bicyclo[3.1.0]hexane-6- carboxylic acid::US10208047, Example 35

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@H]2C[C@H]3[C@@H](C2)[C@H]3C(O)=O)n2ccnc(N)c12)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=OPZHSKJUIKJYJA-JLDVXBSHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350167   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350167((1R,3r,5S,6s)-3-[8-amino-1- (4-{(1R)-1-hydroxy-1-[...)
Affinity DataIC50:  15.7nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent